Coluracetam (BCI-540, MKC-231) is a fat-soluble nootropic in the racetam class, more potent than Piracetam. It boosts brain choline conversion to acetylcholine, improving learning, alertness and attention. It also exhibits anxiolytic qualities and has potential for restoring retinal and optic nerve damage.
Preclinical research suggests that coluracetam preserves high-affinity choline uptake, and may improve working memory deficits in rats. Clinical studies on the drug have reached phase 2a, but are currently discontinued.
What is Coluracetam?
Buy coluracetam Europe is a fast-acting nootropic from the racetam family. It is a very potent compound that only requires a small dosage to feel its effects, which set in rapidly after ingestion. This makes it an excellent addition to a choline supplement or nootropic stack. It is also known to boost memory and learning.
It is fat-soluble, so it is best taken with a meal high in healthy fat to aid absorption and increase bioavailability. It is recommended to start with a low dose and gradually increase it to reduce the risk of side effects. Many people find that taking this nootropic with choline supplements like CDP-Choline or Alpha-GPC improves its effects and helps prevent tolerance.
Coluracetam was originally studied in the 1990s for Alzheimer’s treatment, but the results were never published. Since then, it has been used as a dietary supplement in the US and is sold as a prescription drug in the UK and Canada. It is known to enhance motivation, improve mood and focus, relieve anxiety, and even reverse vision problems.
How Does Coluracetam Work?
Like most racetam nootropics, coluracetam boosts acetylcholine levels in the brain and enhances memory and learning. However, it does this through a different mechanism of action to piracetam. It interacts with the high affinity choline uptake (HACU) process in neurons. This increases the synthesis of acetylcholine from choline. It also makes ACh receptors more sensitive to acetylcholine.
Another interesting aspect of coluracetam is its ability to protect N-Methyl-D-aspartate (NMDA) receptors from glutamate toxicity. NMDA receptors are involved in the formation of long-term potentiation, a process that is involved in memory and learning.
Aside from enhancing cognition, coluracetam also boosts vision by improving color recognition and focusing on shapes. It is also effective in treating irritable bowel syndrome. It can also relieve anxiety and major depressive disorder by increasing acetylcholine. Moreover, it can improve schizophrenic symptoms by restoring hippocampal acetylcholine activity. It has been shown to increase AMPA potentiation, which is a critical component in enhancing cognitive function.
Dosage
Buy coluracetamhas a unique enhancing effect on high affinity choline uptake (HACU), which is crucial to the delivery of choline into neurons for synthesis into acetylcholine, a neurotransmitter involved in memory formation and learning. It also stimulates AMPA receptors, which improves glutamate signaling and boosts cognitive performance.
It shows some promising anxiolytic effects, which may help relieve comorbid anxiety and major depression. It is an effective stimulant without the side effects of traditional caffeine, improving focus and concentration. It can also increase acetylcholine activity in the brain, which could help people suffering from Schizophrenia, where the enzyme responsible for choline synthesis is often impaired. It can also enhance vision through improved color vision and better ability to distinguish shapes and may reduce irritable bowel syndrome symptoms in people with digestive issues.
Coluracetam is sold in a powder form by most vendors and can be taken by mouth or sublingually for more rapid absorption. Some people stack it with a choline supplement such as CDP-Choline or Alpha-GPC to maximize its effectiveness and minimize possible side effects.
Side Effects
Coluracetam is a fat-soluble racetam drug that was developed in the 1990s in Japan for Alzheimer’s treatment. It failed in clinical trials and was repurposed as a dietary supplement by Brain Cells Inc. Studies on it show that it is effective in boosting mood, memory, and learning ability. It also improves anxiety and promotes neurogenesis. It also helps with vision by elevating acetylcholine levels in the brain.
Coluracetam has the ability to boost long-term memory and improves alertness. It works like an ampakine nootropic and blocks NMDA receptor toxicity, which may be a contributor to Alzheimer’s and dementia. It also seems to protect against oxidative damage.
Despite the limited human research, many people rely on it as a cognitive enhancer and mood booster. It’s even more effective than antidepressants because it can help with anxiety and depression simultaneously. Its effects set in faster than most nootropics and are a lot more powerful. It’s also known to boost visual clarity and make colors brighter and sounds crisper.